Systematic discovery of regulatory motifs in human promoters and 3[prime] UTRs by comparison of several mammals:
Comprehensive identification of all functional elements encoded in the human genome is a fundamental need in biomedical research. Here, we present a comparative analysis of the human, mouse, rat and dog genomes to create a systematic catalogue of common regulatory motifs in promoters and 3' untranslated regions (3' UTRs). The promoter analysis yields 174 candidate motifs, including most previously known transcription-factor binding sites and 105 new motifs.
Important biomedical consequences of common descent? Right here. Human, mouse, rat, and dog share regulatory motifs because they share a common ancestor. Understanding them will make it easier to cure diseases and refine treatments.