Cancer biology: Sense out of missense:
The gene encoding the p53 protein is mutated in more than 50% of human cancers, but quite how it is involved in tumour biology has eluded scientists for decades. Studies in Cell by Olive et al.1 and Lang et al.2, of genetically engineered p53 mutant proteins in mice, underscore the complexity of p53 cancer mechanisms, and provide a model for a human cancer-susceptibility syndrome.
It just goes back and forth. Human, mouse, human, mouse. All thanks to a common ancestor.